Polynucleotides are a new treatment used in aesthetic medicine to help regenerate tissues. They are natural, highly purified DNA molecules extracted from salmon. When used for hair restoration, they are prepared in a specific formulation designed to be injected into the scalp.
What are Polynucleotides and How Do They Work?
Many patients ask, “What is a polynucleotide?” Simply put, they are biological molecules that help repair tissue and boost cell renewal. Unlike a skin booster or a filler, polynucleotides act as “biostimulators.”
- Stimulating Hair Follicles: It encourages the hair follicles, which may be dormant or producing fine, miniaturised hairs, to enter a growth phase.
- Improving Scalp Health: It enhances blood circulation in the scalp, delivering more oxygen and nutrients to the hair follicles.
- Reducing Inflammation: Crucial for conditions like Scarring Hair Loss or Alopecia Areata.
This process helps to improve hair density and the quality of the hair shaft, making it thicker and stronger. It is particularly useful for treating smaller, stubborn areas of hair loss that may not be responding as well to other treatments.
Experts in Hair Loss
At IA Dermatology, Dr Iaisha Ali can determine whether you’re experiencing hair shedding or a more serious form of hair loss. Early intervention is key when underlying hair loss is present.
Shree helped me organise an appointment for my consultation among Dr Ali’s busy schedule due to the stress my health issue was causing me. Dr Ali was very understanding & listened to me. She explored all avenues regarding the cause of my hair loss & I walked away feeling positive about the potential outcome.
✅ Verified Patient Review from Doctify
Visited for Hair Loss

Polynucleotides for Hair Loss: What to Expect
During your consultation, Dr. Iaisha Ali will determine if you are a candidate for Vitaran or Plinest, two of the best polynucleotide brands we use for hair density.
- How many sessions of polynucleotides are needed? We generally recommend a course of 3 to 4 sessions.
- How often? Sessions are usually spaced 2–4 weeks apart.
- How long for polynucleotides to work? While some see improvements in scalp health early on, significant hair density changes usually take 3 to 6 months to become visible.
Can Polynucleotides be combined with Microneedling?
Yes. Using Polynucleotides for microneedling is a highly effective way to ensure the DNA fractions reach the deeper layers of the dermis. Combining this with Dermapen Microneedling or RF Microneedling can accelerate the “before and after” results by creating micro-channels that allow for better absorption of the treatment.
Polynucleotide Aftercare and Recovery
The polynucleotide recovery time is minimal. However, to get the most out of your session, follow these steps:
- Polynucleotide Aftercare: Avoid washing your hair for 24 hours to allow the polynucleotide injection points to heal.
- What to expect: You may see small bumps (papules) at the injection site; these are normal and usually disappear within 24 to 48 hours.
- Can you have Polynucleotides and Botox together? Yes, if you are also treating the forehead or brow area, these treatments do not interfere with each other. In fact, many patients treat their hair and face in the same visit.
Revive your hair at IADermatology, Harley Street.
Our Diagnostic Approach
We guide you with realistic timelines, ongoing monitoring, and emotional support.


Clinical examination: Dr. Iaisha Ali assesses hair shedding patterns and scalp health.

Trichoscopy: Non-invasive imaging to examine follicles and rule out other alopecias.

Blood tests or Scalp Biopsy whichever is necessary

Personalised plan: Includes lifestyle changes, treatments, and follow-up care.